Ligand Recognition by β3 Integrins

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著者

    • SUEHIRO Kazuhisa
    • Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, The Cleveland Clinic Foundation
    • PLOW Edward F
    • Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, The Cleveland Clinic Foundation

抄録

Integrins are alpha/bets heterodimeric adhesion receptors. α<sub>IIb</sub>β<sub>3</sub> (GPIIb-IIIa) and α<sub>v</sub>β<sub>3</sub> (the vitronectin receptor) share the same beta subunit, S3, but have distinct alpha subunits. These sister integrins not only recognize many of the same ligands but also have certain unique ligands. Based upon current information in the literature, we propose that four classes of β<sub>3</sub> ligands can be distinguished. Since the β<sub>3</sub> integrins have multiple functions <i>in vivo</i> and are targets for therapy, this classification system may be useful in the design and characterization of therapeutic agents.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 46(3), 111-114, 1997-09-01 

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10021987936
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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