Ligand Recognition by β3 Integrins
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Integrins are alpha/bets heterodimeric adhesion receptors. α<sub>IIb</sub>β<sub>3</sub> (GPIIb-IIIa) and α<sub>v</sub>β<sub>3</sub> (the vitronectin receptor) share the same beta subunit, S3, but have distinct alpha subunits. These sister integrins not only recognize many of the same ligands but also have certain unique ligands. Based upon current information in the literature, we propose that four classes of β<sub>3</sub> ligands can be distinguished. Since the β<sub>3</sub> integrins have multiple functions <i>in vivo</i> and are targets for therapy, this classification system may be useful in the design and characterization of therapeutic agents.
- Keio J. Med.
Keio J. Med. 46(3), 111-114, 1997-09-01
The Keio Journal of Medicine