Rapid Changes in Pial Arterial Diameter and Cerebral Blood Flow Caused by Ipsilateral Carotid Artery Occlusion in Rats

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著者

    • 森田 陽子 MORITA Yoko
    • Department of Neurology, Second Tokyo National Hospital School of Medicine, Keio University Department of Neurology, Second Tokyo National Hospital
    • 福内 靖男 FUKUUCHI Yasuo
    • Department of Neurology, School of Medicine, Keio University Department of Neurology, School of Medicine, Keio University
    • 厚東 篤生 KOTO Atsuo
    • Department of Neurology, School of Medicine, Keio University Department of Neurology, School of Medicine, Keio University
    • 後藤 淳 GOTOH Jun
    • Department of Neurology, School of Medicine, Keio University Department of Neurology, School of Medicine, Keio University
    • 高尾 昌樹 TAKAO Masaki
    • Department of Neurology, School of Medicine, Keio University Department of Neurology, School of Medicine, Keio University

抄録

We investigated rapid changes in pial arterial diameter and in cerebral blood flow (CBF) caused by transient ipsilateral common carotid artery occlusion (CCA-O) in anesthetized rats in order to elucidate how the cerebral circulation reacts to acute stem artery occlusion. In separate groups of rats, pial arterial diameter was recorded through a dosed cranial window and CBF was recorded by laser-Doppler flowmetry. CCA-O was performed for 5 minutes under normotension and normocapnia (control) and under graded hypotension, hypercapnia and hypocapnia. In the control condition, pial arterial diameter increased rapidly, triggered by CCA-O. It took 12±3 s to reach the maximum of 204±42% of the value before CCA-O, and 60±24 s to become stable at 131±11%. CBF decreased rapidly to 66±11%, then increased reactively to 135±9%, and again decreased to 91±3%. The reactive increase in CBF caused by CCA-O decreased in parallel with the degree of hypotension, and also became barely detectable under hypercapnia. Our data suggest that active vascular dilation in the territory of the occluded artery is important for inducing collateral circulation.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 46(3), 120-127, 1997-09-01 

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10021988018
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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