Antitumor Effects and Pharmacological Interaction of Xiao-Chai-Hu-Tang (Sho-Saiko-To) and Interleukin 2 in Murine Renal Cell Carcinoma

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著者

    • 黄 永平 HUANG Yongping
    • Department of Urology, School of Medicine, Keio University Department of Urology, School of Medicine, Keio University
    • 丸茂 健 MARUMO Ken
    • Department of Urology, School of Medicine, Keio University Department of Urology, School of Medicine, Keio University
    • 村井 勝 MURAI Masaru
    • Department of Urology, School of Medicine, Keio University Department of Urology, School of Medicine, Keio University

抄録

Conventional therapy for renal cell carcinoma using interleukin 2 (IL-2) has shown limited antitumor action. The purpose of our study was to investigate synergistic antitumor effects of IL-2 and Xiao-Chai-Hu-Tang (XCHT), and to elucidate the mechanisms of interaction between the two drugs against the murine renal cell carcinoma cell line, Renca, <i>in vivo</i>. The treatment was started 5 days after subcutaneous transplantation of Renca tumor. XCHT was given at a dose of 2.5g/kg daily for 30 days orally. IL-2 was given at a dose of 10<sup>4</sup>U/mouse by subcutaneous injection every other day 8 times. Combination of XCHT and IL-2 inhibited growth of the tumor and prolonged survival significantly as compared with the untreated mice. Increased cellular infiltration was observed in tumor tissue and the lungs of mice treated with XCHT alone and by combination of XCHT and IL-2, but there were no histological changes in the liver and kidney. Elevation of serum IL-6 was observed in tumor-bearing mice, but IL-6 was significantly suppressed by administration of XCHT. The results obtained suggest that combination of XCHT and IL-2 induces enhanced immunological reaction in specific organs and tissues, and IL-6 may have a role in the synergistic effect of these two agents. It was concluded that combination of XCHT and IL-2 is useful in the treatment of patients with renal cell carcinoma.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 46(3), 132-137, 1997-09-01 

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10021988058
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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