Keratinocyte Growth Stimulation by Granulocyte-macrophage Colony-stimulating Factor (GM-CSF)

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著者

    • 田中 勝 TANAKA Masaru
    • Department of Dermatology, University of Wales College of Medicine Department of Dermatology, University of Wales College of Medicine
    • DYKES Peter J
    • Department of Dermatology, University of Wales College of Medicine Department of Dermatology, University of Wales College of Medicine
    • MARKS Ronald
    • Department of Dermatology, University of Wales College of Medicine Department of Dermatology, University of Wales College of Medicine

抄録

Human granulocyte-macrophage colony stimulating factor (GM-CSF) is a 22 kD glycoprotein derived from activated T cells, endothelial cells, fibroblasts and macrophages. It stimulates the proliferation and differentiation of haematopoietic cells and certain nonhaematopoietic cells. This study investigated the effect of GM-CSF on cultured human keratinocytes and determined whether these cells express GM-CSF receptors. Measurement of keratinocyte growth by image analysis showed that GMCSF mildly stimulated the growth of keratinocytes. With 4ng/ml GM-CSF the growth of primary keratinocytes and subcultured keratinocytes was only stimulated up to 25% and 18% of the control cell level, respectively. Human keratinocytes were incubated with GM-CSF at 4 ng/ml for 4 days to induce receptor expression. These cells showed only a weak positive reaction on affinity labelling using digoxigenated GM-CSF. We conclude that keratinocyte growth may be stimulated by GM-CSF but that the presence of GM-CSF receptors on these cells is equivocal.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 46(4), 184-187, 1997-12-01 

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10021988187
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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