Advances in Genomic Research on Hepatitis C Virus with a Useful Tool, Replicon System

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著者

    • NAKAMURA Mitsuyasu
    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University
    • SAITO Hidetsugu
    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University
    • HIBI Toshifumi
    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University

抄録

The research for hepatitis C virus (HCV) has long delayed by missing of <i>in vitro</i> culture system. Since the development of replicon system, a replication system of subgenomic HCV RNAs in a hepatoma cell line, has been reported, many virological and clinical findings have been discovered. Recently, in addition of subgenomic replication system, hepatitis C virus full-length RNA replication has been possible, and a few cell culture systems producing viral particles have been produced. These developments enabled us to investigate the life cycle or intracellular circumstance of HCV production. By screening of newly synthesized drugs with this replicon system, several possible medicines have been established and clinical researches are now running. Among them, VX950 and SCH503034 are nearest to clinical use. Other possible agents for reducing viral replication such as cyclophyllin inhibitors, inhibitors of sphingomyelin synthesis, HMG-CoA reductase inhibitors, or RNA-dependent RNA polymerase inhibitors have been also investigated. Furthermore the mechanism for development of hepatocellular carcinoma in the HCV infected liver has been vigorously studied using the HCV replicon system.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 57(2), 75-83, 2008-06-01 

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10021988439
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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