Collagen Metabolism in the Fibroblasts Derived from the Skin of a 16-year-old Patient with Marfan Syndrome : A Decreased Rate of Intracellular Degradation of Collagen

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著者

    • 多島 新吾 TAJIMA Shingo
    • Department of Dermatology, School of Medicine, Keio University Department of Dermatology, School of Medicine, Keio University

抄録

The rate of collagen synthesis in the cell layer fraction of the skin fibroblasts derived from a patient with Marfan syndrome was greater than that in the normal fibroblasts. Neither the relative content of type III collagen nor the level of prolyl and lysyl hydroxylations in type I collagen changed. Intracellular degradation rate of collagen in Marfan syndrome fibroblasts was decreased to one fifth of that in the normal fibroblasts. These results suggest that abnormal collagen metabolism may be related to the pathogenesis of clinical manifestations of Marfan syndrome.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 44(3), 88-92, 1995-09-01 

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10021988865
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00229717
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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