Characteristic expression of connective tissue components and matrix metalloproteinases (MMPs) during the development of pressure ulcerations

• Mizuno Koji

  Department of Clinical Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences

• Wachi Hiroshi

  Department of Clinical Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences

• Sato Fumiaki

  Department of Clinical Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences

• Onoue Satoshi

  Materials Research Department, Advanced Cosmetic Research Laboratories, KOSE Corporation

• Sakamoto Yoshimitsu

  Department of Environmental Health and Toxicology, Tokyo Metropolitan of Public Health

• Kobayashi Takashi

  Department of Dermatology, National Defense Medical College

• Seyama Yoshiyuki

  Department of Clinical Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences

抄録

Chronic ulcerations are caused by pressure, ischemia or attrition and is a serious problem for long term care. However, little is known about biomolecular markers expressed during the development of pressure ulcerations. In the present study, we examined whether various extracellular matrix components correlate with the development of pressure ulcerations. Examination of wound areas and immunohistological staining showed that pressure ulceration develop following excision of the sciatic nerve from the hindlimbs of mice. Our data reveal that the expression of mRNAs encoding type I collagen (collagen α1 (I)), type IV collagen (collagen α1 (IV)), matrix metalloproteinase (MMP)-2, -3 and -9 correlate with the wound area. But laminin- 5 (laminin-5 α3) does not correlate with the wound area. These results suggest that the expression of those mRNAs provides specific biomolecular markers for pressure ulcerations. The present study will be useful for developing effective therapeutic agents or prophylactic agents against pressure ulcerations.

収録刊行物

• Inflammation and Regeneration

  Inflammation and Regeneration 28 (1), 47-52, 2008

  一般社団法人 日本炎症・再生医学会

キーワード

• extracellular matrix
• matrix metalloproteinase
• mRNA expression
• pressure ulceration
• skin

詳細情報

• CRID: 1390282680235297920
• NII論文ID: 130004482207
• NII論文ID: 10022602192
• NII書誌ID: AA11508953
• DOI: 10.2492/inflammregen.28.47
• ISSN: 18808190
• ISSN: 18809693
• NDL書誌ID: 9369068
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9369068
• Web Site: https://search.jamas.or.jp/link/ui/2008201756
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可