The effect of geranylgeranylacetone on human osteoclastogenesis and synovitis in patients with rheumatoid arthritis

• Nanke Yuki

  Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

• Kotake Shigeru

  Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

• Kamatani Naoyuki

  Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

抄録

Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with synovitis and bone destruction. The levels of monocyte/macrophage-derived cytokines, including TNFα, interleukin-1 (IL-1), and IL-6, and the T cell-derived cytokine, IL-17, all of which are involved in the pathogenesis of RA, are elevated in the synovial fluid of RA patients.<BR>Geranylgeranylacetone (GGA), an acyclic polyisoprenoid known as teprenone, has been widely used as an antiulcer drug. We have reported that GGA inhibits human osteoclastgenesis, and that GGA increases the bone mineral density in ovariectomized rats and tail-suspended rats. These effects are due to inhibiting the prenylation of geranylgeranylpyrophosphate (GGPP) by GGA in the mevalonate pathway. Recently, we also demonstrated that GGA induces cell death in fibroblast-like synoviocytes from patients with RA. These findings suggest that GGA may be available as a new agent for RA and osteoporosis.

収録刊行物

• Inflammation and Regeneration

  Inflammation and Regeneration 28 (2), 111-116, 2008

  一般社団法人 日本炎症・再生医学会

キーワード

• apoptosis
• geranylgeranylation
• rheumatoid arthritis
• synovitis
• statin

詳細情報

• CRID: 1390282680232924672
• NII論文ID: 130004482214
• NII論文ID: 10022602370
• NII書誌ID: AA11508953
• DOI: 10.2492/inflammregen.28.111
• ISSN: 18808190
• ISSN: 18809693
• NDL書誌ID: 9469660
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9469660
• Web Site: https://search.jamas.or.jp/link/ui/2008247915
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可