Jun N-Terminal Kinase Inhibitor Blocks Angiogenesis by Blocking VEGF Secretion and an MMP Pathway

• Miura Shin-ichiro

  Department of Cardiology, Fukuoka University School of Medicine.

• Matsuo Yoshino

  Department of Cardiology, Fukuoka University School of Medicine.

• Saku Keijiro

  Department of Cardiology, Fukuoka University School of Medicine.

抄録

Aim: The excessive proliferation and migration of vascular smooth muscle cells (SMCs) and angiogenesis of endothelial cells (ECs) participate in the growth and instability of atherosclerotic plaques. It is unclear whether Jun N-terminal kinase (JNK) is pro-or anti-atherogenic.<BR>Methods: We examined the direct effect of JNK inhibitor (JNK-I) on the proliferation and formation of tubes by human coronary SMCs and human coronary ECs.<BR>Results: Culture medium from JNK-I-treated SMCs prevented ECs from forming tubes in an in vitro model of angiogenesis indirectly by reducing the amount of vascular endothelial growth factor (VEGF) released from SMCs. In addition, JNK-I attenuated the expression of pro-matrix metalloproteinase-2 in ECs. When added back to the medium of SMCs treated with JNK-I, VEGF blocked the inhibitory effect on the formation of tubes.<BR>Conclusion: Our results indicate JNK-I to have a direct anti-atherogenic effect in SMCs and ECs.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 15 (2), 69-74, 2008

  一般社団法人 日本動脈硬化学会

キーワード

• Jun N-terminal kinase
• Tube formation
• Vascular endothelial growth factor
• Matrix metalloproteinase

詳細情報

• CRID: 1390282679409653504
• NII論文ID: 10022607978
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.e496
• ISSN: 18803873
• ISSN: 13403478
• Web Site: https://www.jstage.jst.go.jp/article/jat/15/2/15_E496/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008292847
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可