NT-702, a Selective Phosphodiesterase 3 Inhibitor, Dilates Rabbit Spinal Arterioles via Endothelium-Dependent and Endothelium-Independent Mechanisms
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- Mizuno Risuke
- Department of Physiology, Shinshu University School of Medicine
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- Watanabe Sachiko
- Department of Physiology, Shinshu University School of Medicine
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- Ohhashi Toshio
- Department of Physiology, Shinshu University School of Medicine
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We investigated the effects of NT-702, a selective phosphodiesterase (PDE) 3 inhibitor, on arterioles isolated from rabbit lumbar spinal cords. NT-702 caused a dose-dependent dilation of the isolated spinal arterioles. The disruption of endothelium produced a significant reduction of higher concentrations (10–7 and 10–6 M), but not lower concentrations (less than 10–8 M), of NT-702–induced vasodilation. The NT-702–induced vasodilation of the arterioles with endothelium was not affected by pretreatment with an inhibitor of nitric oxide, cyclooxygenase, or cytochrome P-450 monooxygenase. In contrast, catalase reduced significantly the higher concentrations of NT-702–induced vasodilation only. Tetraethylammonium (TEA) completely reduced the lower concentrations of NT-702–induced vasodilation, but decreased only partially the higher concentrations of NT-702–induced vasodilation of the arterioles with endothelium. Hydrogen peroxide dilated significantly the isolated arterioles with endothelium, the response of which was reduced significantly by TEA. KT5720 (a selective protein kinase inhibitor) significantly decreased both the lower and higher concentrations of NT-702–induced vasodilation of the arterioles with endothelium. The findings suggest that NT-702 dose-dependently dilated the isolated spinal arterioles of rabbits via endothelium-dependent and endothelium-independent mechanisms. Protein kinase A (PKA)- and TEA-sensitive K+ channels may be involved in the NT-702–induced vasodilation. Moreover, hydrogen peroxide may contribute in part to the endothelium-dependent higher concentrations of NT-702–induced vasodilation.<br>
収録刊行物
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- The Journal of Physiological Sciences
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The Journal of Physiological Sciences 58 (4), 229-237, 2008
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680226898176
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- NII論文ID
- 10023966352
- 130004466929
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- NII書誌ID
- AA12129145
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- ISSN
- 18806562
- 18806546
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- NDL書誌ID
- 9618498
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- PubMed
- 18558016
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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