Quantitative Analysis of the Ultrasonic Vocalization Responses Elicited in Adjuvant-Induced Arthritic Rats for Screening Analgesic Drugs

• NAITO Hiroyuki

  Department of Physiology , School of Veterinary Medicine, Azabu University

• INOUE Maki

  Department of Physiology , School of Veterinary Medicine, Azabu University

抄録

Adjuvant-induced arthritic (AIA) rats have been developed as a chronic pain model to evaluate the effects of analgesic drugs. The purpose of the present study was to examine whether there is dose-dependent inhibition of the emission of ultrasonic vocalization (USV) responses by analgesic drugs in AIA rats. It was demonstrated that morphine (1.25-5.0 mg/kg, s.c.) and ketoprofen (2.5-10.0 mg/kg, s.c.) dose-dependently inhibit USV responses. These results suggest that the USV responses elicited in AIA rats are useful for the quantitative evaluation of analgesic drugs.<br>

収録刊行物

• Experimental Animals

  Experimental Animals 57 (4), 419-422, 2008

  公益社団法人 日本実験動物学会

キーワード

• adjuvant-induced arthritic rats
• ketoprofen
• morphine
• naltrexone
• ultrasonic vocalization

詳細情報

• CRID: 1390001205044052736
• NII論文ID: 130000067984
• NII論文ID: 10024166655
• NII書誌ID: AA11032321
• DOI: 10.1538/expanim.57.419
• ISSN: 18817122
• ISSN: 00075124
• ISSN: 13411357
• NDL書誌ID: 9566165
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9566165
• Web Site: http://www.jstage.jst.go.jp/article/expanim/57/4/57_4_419/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009001469
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可