Organization of Multisynaptic Inputs from the Parietal Association Cortex to the Primary Motor Cortex

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  • Sawada Kaori
    Division of Applied System Neuroscience, Department of Advanced Medical Science, Nihon University School of medicine Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience
  • Miyachi Shigehiro
    Department of Behavioral and Brain Sciences, Primate Research Institute, Kyoto University
  • Yamashita Akiko
    Division of Applied System Neuroscience, Department of Advanced Medical Science, Nihon University School of medicine
  • Imanishi Michiko
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience
  • Katsuyama Narumi
    Division of Applied System Neuroscience, Department of Advanced Medical Science, Nihon University School of medicine
  • Taira Masato
    Advanced Research Institute for the Sciences and Humanities, Nihon University
  • Takada Masahiko
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience

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Other Title
  • 大脳皮質頭頂連合野から一次運動野への多シナプス性投射様式―狂犬病ウイルスを用いた研究―
  • ダイノウヒシツ トウチョウ レンゴウヤ カラ 1ジ ウンドウヤ エノ タシナプスセイ トウシャ ヨウシキ キョウケンビョウ ウイルス オ モチイタ ケンキュウ
  • ―狂犬病ウイルスを用いた研究―

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Abstract

The parietal association cortex has been considered to play important roles in the integration of a variety of sensory information. Recent studies have revealed that this cortical area also participates in motor control. Since there are no direct neuronal connections between the parietal association cortex and the primary motor cortex that controls somatic movements, the parietal information could be sent to the primary motor cortex indirectly via two or more synapses. However, the existence of such multisynaptic pathways has not yet been demonstrated experimentally. Rabies virus selectively infects neuronal cells and moves across synapses in a retrograde direction. Therefore, the use of this virus as a neuronal tracer enables us to visualize the entire organization of a specific neural circuit. In the present study, we injected the virus into the hindlimb, proximal forelimb, and distal forelimb representations of the primary motor cortex in macaque monkeys and analyzed the distribution patterns of second-order neurons (labeled disynaptically) in the parietal association cortex. We found that such parietal projections to the primary motor cortex are organized in a somatotopic fashion.

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