コラーゲン誘導関節炎ラットの下顎頭軟骨における細胞外マトリックスの変化とMMP‐3の発現

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  • Changes in extracellular matrix and MMP-3 expression in the mandibular condylar cartilage of collagen-induced arthritis rats

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis and progressive destruction of the joints. In this study, we investigated changes in the extracellular matrix of mandibular condylar cartilage after experimentally inducing arthritis, using histological examination, immunohistochemistry and molecular biology.<BR>According to changes in the gross score for the left hind paw in DA rats after immunization with type II collagen, all rats were evaluated with a score of over 3 after immunization at 18 days. Although mandibular condylar cartilage destruction was slight histologically, stainability for type II collagen, chondroitin 4-sulfate and chondroitin 6-sulfate gradually became weaker. The expression of MMP-3mRNA in the condylar cartilage showed an increase on quantitative real-time PCR 2 weeks after immunization. These findings suggest that changes in the extracellular matrix of the mandibular condylar cartilage occur in the early stage of arthritis and that MMP-3 plays a crucial role in the pathogenesis of arthritic destruction.

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