The Effect of Loratadine on Psychomotor Function in Healthy Japanese Subjects: Comparison with d-Chlorpheniramine Maleate and Placebo in a Double-Blind 4-Way Crossover Study
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- NAKANO Shigeyuki
- Department of Pharmaceutical Medicine, Oita University Faculty of Medicine International University of Health and Welfare Graduate School
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- SUNAMI Yukiko
- Kyushu Clinical Pharmacology Research Clinic, Medical Co. LTA
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- IRIE Shin
- Department of Pharmaceutical Medicine, Oita University Faculty of Medicine Kyushu Clinical Pharmacology Research Clinic, Medical Co. LTA
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- MATSUGUMA Kyoko
- Kyushu Clinical Pharmacology Research Clinic, Medical Co. LTA
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- TSUKIKAWA Hiroshi
- Kyushu Clinical Pharmacology Research Clinic, Medical Co. LTA
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The effect of loratadine, a new antihistamine, on psychomotor function was investigated in healthy Japanese volunteers using accuracy of typing figures into a personal computer as the index in a Latin-square double-blind crossover study with d-chlorpheniramine maleate as positive control and placebo as negative control. Twenty subjects typed figures for 15 minutes at 2 hours after receiving a single dose of 10 mg or 20 mg of loratadine after breakfast. The number of correct entries was counted automatically per subject as the primary variable. In the chlorpheniramine group the number of correct entries was significantly less than in the placebo and loratadine 10 mg and 20 mg groups (p<0.05, p<0.05, and p<0.01, respectively). No significant difference was observed between the placebo, loratadine 10 mg, and loratadine 20 mg groups. The results suggest that loratadine, unlike d-chlorpheniramine maleate, does not affect psychomotor function at either the usual dose of 10 mg or at twice the usual dose (20 mg).
収録刊行物
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- 臨床薬理
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臨床薬理 38 (6), 401-407, 2007
一般社団法人 日本臨床薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205368863872
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- NII論文ID
- 10024186987
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- NII書誌ID
- AN0025404X
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- COI
- 1:CAS:528:DC%2BD1cXitVans7c%3D
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- ISSN
- 18828272
- 03881601
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 使用不可