りんご枝おがくずを培地とした鹿角霊芝の肝機能保護作用  [in Japanese] Protective Action of Hepatic Function by Dietary Antlered Form of Ganoderma lucidum Using Sawdust of Apple Branch as Medium  [in Japanese]

6週齢ICR雄マウスにりんご鹿角霊芝（AAFGL）を含む飼料を11日間与えた後に，腹腔内に四塩化炭素（CCl4，40μL/kg）を投与した後の肝機能障害緩和効果を検証した．その結果，AAFGL非摂取（対照）群と比べて，AAFGL摂取群の肝機能指標酵素活性の上昇は抑えられ，血清TNF-α濃度は低くなる傾向にあった．また，肝臓トリグリセリド濃度も同様の傾向を示した．肝臓過酸化脂質濃度は対照群と比べてAAFGL摂取群は有意に低くなり，反対に，トコフェロール濃度は高くなった．赤血球抗酸化酵素の中でも，カタラーゼとグルタチオンペルオキシダーゼ活性は対照群と比べてAAFGL摂取は高い傾向にあった．このように，CCl4によって誘導される肝機能障害と生体内抗酸化システムの変動はAAFGLの摂取で制御できる可能性が示唆された．

This study investigated the ameliorative effect of dietary apple antlered form of Ganoderma lucidum (AAFGL) in mice with carbon tetrachloride (CCl4)-induced liver injury. Male ICR mice (6 weeks, n=6-7per group) were divided into control and 1% AAFGL groups. Mice were given test diets for 11 days before intraperitoneal injection with CCl4 (40μL/kg). Dietary AAFGL inhibited the abnormal increase of GOT, GPT, and LDH in serum. The serum TNF-α and the liver triglyceride levels tended to be lower in the AAFGL-fed group than in the control. The liver TBARS level was significantly lower in the AAFGL-fed group than in the control, however, the liver tocopherol level was significantly higher in AAFGL-fed group than in the control. Moreover, the erythrocytic catalase and glutathione peroxidase activities in AAFG-fed group were higher than those in the control. Thus, dietary AAFGL may exert protective function against liver damage and modulation of antioxidant system induced by CCl4.