Relationship between genetic polymorphism of arsenic (+3 oxidation state) methyltransferase (AS3MT) and profile of urinary arsenic compounds in Vietnamese
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- Agusa Tetsuro
- Center for Marine Environmental Studies(CMES),Ehime University Department of Legal Medicine, Shimane University, Faculty of Medicine
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- Fujihara Junko
- Department of Legal Medicine, Shimane University, Faculty of Medicine
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- Takeshita Haruo
- Department of Legal Medicine, Shimane University, Faculty of Medicine
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- Iwata Hisato
- Center for Marine Environmental Studies(CMES),Ehime University
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- Minh Tu Binh
- Center for Marine Environmental Studies(CMES),Ehime University Department of Biology and Chemistry(BCH),City University of Hong Kong Center for Environmental Technology and Sustainable Development(CETASD)
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- Trang Pham Thi Kim
- Center for Environmental Technology and Sustainable Development(CETASD)
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- Viet Pham Hung
- Center for Environmental Technology and Sustainable Development(CETASD)
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- Tanabe Shinsuke
- Center for Marine Environmental Studies(CMES),Ehime University
書誌事項
- タイトル別名
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- Relationship between Genetic Polymorphism of Arsenic(+3 oxidation state) Methyltransferase(<i>AS3MT</i>)and Profile of Urinary Arsenic Compounds in Vietnamese
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抄録
We investigated genetic polymorphism of 287Met>Thr(Met-to-Thr substitution at amino acid base 287)in arsenic(+3 oxidation state)methyltransferase(AS3MT),which is an S-adenosyl-L-methionine-dependent enzyme that catalyzes the methylation of arsenite(AsIII)and methylated As, and its relation to urinary arsenic profile in 100 individuals from the Red River Delta, Vietnam. Allele mutation frequency(2%)in this population was similar to that in other Asian populations, but relatively lower than those in Caucasians and Africans. Dimethylarsinic acid was the predominant compound in urine, followed by arsenobetaine. Low levels of inorganic arsenic(IA)and monomethylarsonic acid(MMA)were also detected. Concentration ratio of urinary MMA/IA for TC heterozygote was significantly higher than that for TT homozygote, suggesting higher methylation capacity from IA to MMA in individuals with TC.
収録刊行物
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- Biomedical Research on Trace Elements
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Biomedical Research on Trace Elements 19 (3), 265-267, 2008
日本微量元素学会
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詳細情報 詳細情報について
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- CRID
- 1390001204365843456
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- NII論文ID
- 130004456869
- 10024400787
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- NII書誌ID
- AN10423256
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- ISSN
- 18801404
- 0916717X
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- NDL書誌ID
- 9714370
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可