家畜と実験動物における一遺伝子座とマーカーとの連鎖の確率

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  • The Probability of a Linkage between Marker and a Locus in Livestock and Laboratory Animals
  • Probability of a Linkage between Marker

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The probability of a linkage with assigned tightness between one of the markers and a locus was evaluated in some species of livestock and laboratory animals. The locus was assumed to control a trait. The tightness of the linkage was arbitrarily assignable as the physical distance: d. between the nearest marker and a locus in the evaluation. When d was relatively small; up to 1-2% of total autosomal genome size, the probability of a linkage; Pr (D ≤d), increased rapidly with increasing d. The rate of increase in the probability declined with further increment of d. The probability was determined almost entirely by the haploid number of autosomal chromosome in the animals considered. If the number of marker; m, was an assigned value, e. g. m=50, the Pr (D≤d) was higher for animals with smaller number of chromosome and the differences among animals gradually increased with d. When d was 5% of autosomal genome size and m was 50, the linear regression coefficient of the Pr (D≤d)on the haploid number of autosomal chromosome was-.0076 and the simple correlation coefficient between these two was 0.98. The probability of a linkage at d is 5% of autosomal genome size increased with increasing m and the differences in the Pr (D≤d) among Chinese hamster (n=10), rat (n=20) and cattle (n=29) maximized at m was 20. The differences reduced either m was greater or smaller than 20. In swine, it requires about 500 randomly distributing markers to find alinkage between one of the markers and a locus within 0.25 percent of autosomal genome size distance; i. e. 5 centi Morgan, with higher probability than 0.9.

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