テラヘルツ分光スペクトル測定による市販製剤の分析例

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  • A Trial of Analysis for Commercially Available Medicine by Terahertz Spectroscopy

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<p>A Terahertz (THz) wave has distinctive characteristics of high transmittance for many objects such as radio waves, and straight advancement such as ordinary light. Vibration spectra of weak intermolecular interactions such as hydrogen bonding and van der Waals' force can be detected in the THz region. Skeletal vibrations of the molecule and phonon modes of organic crystals also lie in this frequency band. Since THz spectra is sensitive to molecular structure and crystal formation, THz spectrometry is expected to be useful to detect deterioration or transformation of medicines (e.g. oxidation, hydration, crystal modification, isomerization). The high resolution and wide-frequency band of our spectrometer have considerable potential for molecular vibration analysis in the THz range.</p><p>We successfully applied THz spectroscopy to commercially available vitamin tablets provided from four manufacturers. THz spectrometry was able to recognize the manufacturer of each tablet. It could also be used for component analysis of medicine using the differential spectrum method and comparison with a database. For practical use, construction of a THz spectra database including all medicines and their contents is strongly needed at first. If the components of the medicine show polymorphism, like vitamin B2, the medicine can be distinguished from other forms even though they have the same contents.</p>

収録刊行物

  • 薬剤学

    薬剤学 68 (4), 297-305, 2008

    公益社団法人 日本薬剤学会

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