Three Cases of Anorectal Malignant Melanoma

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  • 直腸肛門部悪性黒色腫の３例

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Abstract

Anorectal malignant melanoma is a relatively rare disease with poor prognosis. Herein, we report three cases of anorectal melanoma. Case 1: A 50's man complained of rectal bleeding at evacuation. A soft, soy-bean-sized mass was palpated by digital rectal examination, and the biopsy specimen showed malignant melanoma. He underwent abdominoperineal rectal resection (APR) and four cycles of DAV as postoperative adjuvant chemotherapy. Currently, he has been disease-free for 9 years. Case 2: A 60's woman with bloody stool was found to have a black, easily-bleeding mass on a dentate line. Histological examination of the biopsy revealed malignant melanoma. DAVferon chemotherapy and local administration of IFNβ were performed, followed by APR. Twenty-six months after operation, she was found to have liver and lung metastasis, and died 9 months thereafter. Case 3: A 40's woman was accidentally found to have pigmentation of the rectum while undergoing an operation for myoma uteri. It was surgically removed, but since it was shown to be malignant melanoma by histology, APR was performed subsequently. In addition, she received four cycles of DAVferon postoperative adjuvant chemotherapy. She has remained alive for 21 months without recurrence.<br>

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