Dexamethasone Enhances Fertility and Preovulatory Serum Prolactin Levels in eCG/hCG Primed Immature Rats

• ROCKWELL L. Christie

  Department of Anthropology, Temple University

• KOOS Robert D.

  Department of Physiology, University of Maryland School of Medicine

抄録

Glucocorticoids have heterogeneous effects on reproductive function. We used a gonadotropin-primed, immature rat model to study the influence of dexamethasone (1 mg/kg), given during the latter stages of follicular development, on litter size, the number of oocytes released, and pituitary hormone levels. Dexamethasone-treated females released a larger number of oocytes at ovulation and gave birth to larger litters indicating the oocytes were viable. Survival to weaning age was not affected but average weight at weaning was lower for pups born to DEX-treated females. Serum FSH and LH were assayed at 12, 24 and 48 h following eCG and did not differ between dexamethasone-treated and control animals, but prolactin showed a prolonged pattern of elevation in DEX-treated females. Prolactin, which normally exhibits an elevation on proestrous, may modulate follicular development. Dexamethasone enhances fertility and fecundity possible through an effect of prolactin on follicle development, or by other direct effects on the ovary. These results may improve our understanding of the usefulness of DEX in assisted reproductive therapies for women.<br>

収録刊行物

• Journal of Reproduction and Development

  Journal of Reproduction and Development 55 (3), 247-251, 2009

  公益社団法人 日本繁殖生物学会

キーワード

• Fecundity
• Glucocorticoids
• Ovary

詳細情報

• CRID: 1390001206336128384
• NII論文ID: 10024942178
• NII書誌ID: AA10936678
• DOI: 10.1262/jrd.20108
• ISSN: 13484400
• ISSN: 09168818
• Web Site: http://www.jstage.jst.go.jp/article/jrd/55/3/55_20108/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010040963
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可