Food Deprivation Induces Monocarboxylate Transporter 2 Expression in the Brainstem of Female Rat

• MATSUYAMA Shuichi

  National Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization

• OHKURA Satoshi

  Department of Bioengineering Sciences, Graduate School of Bioagricultural Sciences, Nagoya University

• IWATA Kinuyo

  Department of Bioengineering Sciences, Graduate School of Bioagricultural Sciences, Nagoya University

• UENOYAMA Yoshihisa

  Department of Bioengineering Sciences, Graduate School of Bioagricultural Sciences, Nagoya University

• TSUKAMURA Hiroko

  Department of Bioengineering Sciences, Graduate School of Bioagricultural Sciences, Nagoya University

• MAEDA Kei-ichiro

  Department of Bioengineering Sciences, Graduate School of Bioagricultural Sciences, Nagoya University

• KIMURA Koji

  National Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization

抄録

Ketone bodies are considered to act as a signal to suppress gonadotropin release during negative energy balance. The present study examined the effect of 48-h fasting on the mRNA expressions of monocarboxylate transporter 1 (MCT1) and MCT2, which are involved in ketone body transport, in several brain regions. Quantitative real-time RT-PCR analysis showed that the MCT2 mRNA levels were significantly increased by 48-h fasting in the area postrema-solitary tract nucleus (AP-NTS) region but not the arcuate nucleus-ventromedial hypothalamic nucleus (ARC-VMH) and central gray-supragenual nucleus around the 4th ventricle (CG-SGe) regions. Fasting did not significantly affect MCT1 mRNA expression in any of the brain areas examined. Luteinizing hormone (LH) pulse frequency significantly decreased and plasma concentrations of β-hydroxybutyric acid, a ketone body, significantly increased after 48-h fasting. The present results suggest that increased uptake of ketone bodies via MCT2 in the AP-NTS region is likely involved in the mechanism of fasting-induced suppression of LH secretion in rats.<br>

収録刊行物

• Journal of Reproduction and Development

  Journal of Reproduction and Development 55 (3), 256-261, 2009

  公益社団法人 日本繁殖生物学会

キーワード

• Fasting
• Ketone body
• Luteinizing hormone
• Monocarboxylate transporter

詳細情報

• CRID: 1390001206336130688
• NII論文ID: 10024942246
• NII書誌ID: AA10936678
• DOI: 10.1262/jrd.20214
• ISSN: 13484400
• ISSN: 09168818
• NDL書誌ID: 10257817
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10257817
• Web Site: http://www.jstage.jst.go.jp/article/jrd/55/3/55_20214/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010040965
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可