Localized cerebral blood flow changes in response to ADL-related vitality in elderly patients with dementia using single photon emission computed tomography

• Sonohara Kazuki

  Department of Geriatric Medicine, Kyorin University School of Medicine

• Toba Kenji

  Department of Geriatric Medicine, Kyorin University School of Medicine

• Nakai Ryuhei

  Department of Geriatric Medicine, Kyorin University School of Medicine

• Kobayashi Yoshio

  Department of Geriatric Medicine, Kyorin University School of Medicine

• Moriya Yukiko

  Department of Geriatric Medicine, Kyorin University School of Medicine

• Hasegawa Hiroshi

  Department of Geriatric Medicine, Kyorin University School of Medicine

• Kozaki Koiti

  Department of Geriatric Medicine, Kyorin University School of Medicine

• Matsuda Hiroshi

  Department of Nuclear Medicine, Saitama Medical School

Bibliographic Information

Other Title

• 認知症高齢者の意欲低下に関連する脳血流分布
• イブニングセミナー 老年期における認知症のトピックス 認知症高齢者の意欲低下に関連する脳血流分布
• イブニング セミナー ロウネンキ ニ オケル ニンチショウ ノ トピックス ニンチショウ コウレイシャ ノ イヨク テイカ ニ カンレンスル ノウ ケツリュウ ブンプ

Abstract

Aim: To clarify the area in the brain related to responsible for vitality and volition.<br> Methods: We studied 123 outpatients (39 men, 84 women, 77.7±6.7 years old) who visited the Center for comprehensive care on memory disorders in Kyorin University Hospital. No patients were prescribed with anti-depressants, anti-anxiety agents, psychomimetics, acetylcholinesterase inhibitors, Chinese herbal medicines or cerebrovascular circulation modifying drugs. Patients with frontotemporal dementia or depression were excluded. ADL-related vitality and volition was measured by a vitality index. Cerebral brain blood flow was measured by single photon emission computed tomography (^99mTc-ECD SPECT). Relative blood flow changes were calculated by Statistical Parametric Mapping (SPM). Absolute blood flow changes were calculated by a three-dimensional stereotaxic ROI template on anatomically standardised ^99mTc-ECD SPECT (3D SRT). Statistically significant correlations between semi-quantitatively measured scores of vitality index and blood flow changes in SPM and 3D-SRT were tested and displayed on a brain map.<br> Results: Analysis of ralative and absolute blood flow showed that the common responsible area in the brain related to vitality was the frontal lobe, fronto-cingulate gyrus, temporal lobe, basal ganglia (caudate nucleus) and thalamus. Blood flow changes in the orbital gyrus were strongly correlated with vitality index specially in the frontal lobe.<br> Conclusion: ADL-related vitality is affected mainly by the blood flow in the frontal-subcortical circuit. However, deep white matter was also important to determine vitality and volition.<br>

Journal

• Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics

  Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 45 (6), 615-621, 2008

  The Japan Geriatrics Society

Keywords

• Dementia
• Vitality
• Vitality index
• SPECT
• Deep white matter

Details

• CRID: 1390282680001018880
• NII Article ID: 10024963441
• NII Book ID: AN00199010
• DOI: 10.3143/geriatrics.45.615
• NDL BIB ID: 9763288
• ISSN: 03009173
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9763288
• Web Site: https://search.jamas.or.jp/link/ui/2009099373
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed