Effects of Bidens pilosa L. var. radiata SCHERFF treated with enzyme on histamine-induced contraction of guinea pig ileum and on histamine release from mast cells

DOI Web Site 被引用文献1件 参考文献17件
  • Matsumoto Takayuki
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
  • Horiuchi Masako
    Department of Clinical Chemistry, Hoshi University
  • Kamata Katsuo
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
  • Seyama Yoshiyuki
    Department of Clinical Chemistry, Hoshi University

この論文をさがす

抄録

The medical mechanism against type I allergies is to block the release or production of chemical mediators from mast cells or to block the H1-receptor signaling. We previously reported that the anti-allergic action of the dry powder from Bidens pilosa L. var. radiata SCHERFF treated with the enzyme cellulosine (eMMBP) was dependent on the inhibition of histamine release from mast cells. Here, we investigate that the effect of fractions in eMMBP on the histamine-induced contraction in guinea pig ileum and on the release of histamine in rat peritoneal mast cells. The histamine-induced contraction in guinea pig ileum is dose-dependently inhibited by ketotifen, an antagonist of H1-receptor. Fractions contained caffeic acid, caffeoylquinic acid and fractions contained flavonoids such as hyperin and isoquercitrin in eMMBP inhibit histamine release from mast cells, but only flavonoids such as hyperin, isoquercitrin and rutin suppress the histamine-induced contraction in guinea pig ileum. Moreover, the histamine-induced contraction was not affected by caffeic acid, however, such contraction was significantly inhibited by rutin. These results suggest that the primary antagonists of H1- receptor are different from the components in eMMBP that inhibit histamine release, and that these components participate in the anti-allergic activity of eMMBP.<br>

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (17)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ