フェリプレシンの心機能に与える影響―ＧＯＳ麻酔下における検討―

DOI 被引用文献1件 参考文献11件

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タイトル別名
  • Influence of felypressin on human cardiovascular system-Study of under GOS general anesthesia-
  • —Study of under GOS general anesthesia—
  • ―GOS麻酔下における検討―

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We investigated the influence of felypressin on the human cardiovascular system.<BR>As subjects, twelve ASA I or II patients underwent orthognathic surgery under GOS general anesthesia. They were divided into two groups : one group received 30mL of 2 % propitocaine (group P) and the other group received 20mL of 3 % propitocaine with 0.03IU/mL f elypressin (group FP) . One hour before operation the patients received 10mg of diazepam syrup for premeditation. In the operation room, we administered 2 mg / kg propof ol, 0.1mg / kg vecuronium, 6 L / min O2and 4 % sevoflurane for tracheal intubation. Anesthesia was maintained at 4 L/min N2O, 2 L/min O2and 1 % sevoflurane during measurement. Before local anesthetic injection, we took control values of cardiac output, blood pressure and heart rate. After injection, we took each value at 2 minutes, 4 minutes, 6 minutes and 8 minutes later. Cardiac output was measured by Pulse Dye Densito-Graph® (Ni on Kohden Industrial), and blood pressure and heart rate were measured by BP-508® (Nihon Kohrin Industrial) .<BR>Statistical analysis was performed with the unpaired t-test between group P and group FP, and ANOVA and Tukey's tests were performed between the control values and values at each time. Each data was expressed as a percentage of the control value.<BR>There was a tendency toward decreased blood pressure when felypressin was administered, which was considered to be caused by decreased cardiac output which exceeded total peripheral resistance. There was also a tendency toward decreased heart rate. However, we could not explain the cause of the phenomenon. Cardiac output was significantly decreased by felypressin administration, which was considered to be caused by increased afterload due to augmentation of total peripheral resistance and decreased myocardial contractility due to decreased coronary blood flow.<BR>These results suggest that felypressin can prevent an increase in blood pressure and is suitable for hypertension patients. Care is needed, however, for patients with ischemic heart disease or heart failure.

収録刊行物

  • 歯科薬物療法

    歯科薬物療法 23 (2), 41-45, 2004

    日本歯科薬物療法学会

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