茶葉中メチル化カテキンの抗アレルギー作用

• 山本（前田） 万里

  独立行政法人 農業・食品産業技術総合研究機構 野菜茶業研究所

書誌事項

タイトル別名

• Anti-allergic action of O-methylated catechin in tealeaves.
• チャバ チュウ メチルカ カテキン ノ コウアレルギー サヨウ

抄録

O-Methylated (−)-epigallocatechin gallates (EGCGs) have an anti-allergic action, and the Japanese tea cultivar ‘Benifuuki’ is rich in EGCG3''Me, which is lost due to processing in black tea. Oral administration of O-methylated EGCGs significantly and dose-dependently inhibited type I allergic reactions in mice. O-methylated EGCGs also strongly inhibited mast cell activation through the prevention of tyrosine phosphorylation of cellular protein and high-affinity IgE receptor expression, as well as histamine/leukotriene release. Over a one-month period, drinking ‘Benifuuki’ green tea was useful to reduce some of the symptoms of Japanese cedar pollinosis, and did not affect any normal immune response in subjects with seasonal rhinitis. The AUC (area under the drug concentration time curve) of EGCG3''Me was 6.4 times that of EGCG in healthy human volunteers. Furthermore, many foods and household goods used ‘Benifuuki’ green tea were developed and sold by several manufacturers.<br>

収録刊行物

• 生物物理化学

  生物物理化学 53 (2), 37-40, 2009

  日本電気泳動学会

キーワード

• <i>O</i>-methylated catechin
• anti-allergic action
• ‘Benifuuki’ green tea
• mast cell

詳細情報

• CRID: 1390001204202928768
• NII論文ID: 10025708039
• NII書誌ID: AN00129729
• DOI: 10.2198/sbk.53.37
• COI: 1:CAS:528:DC%2BD1MXnsl2lsro%3D
• ISSN: 13499785
• ISSN: 00319082
• NDL書誌ID: 10343814
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10343814
• Web Site: https://search.jamas.or.jp/link/ui/2009247110
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可