皮膚原発ｍａｒｇｉｎａｌ　ｚｏｎｅ　ｌｙｍｐｈｏｍａの１例

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  • A case of primary cutaneous marginal zone lymphoma.

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A 49-year-old female noticed a gradually enlarging tumor on her right cheek in August, 1993. She had had no general symptoms, insect bite or injury. The tumor was 13mm in diameter, dark-red and dome-shaped without tenderness or adhesion to the fascia. The lesion was diagnosed as a benign lymphocytoma cutis by biopsy and resected in November 10, 1993. Histopathologically there was a grenz zone with in the epidermis and massive dense lymphocytic infiltration from the upper dermis to the subcutis. Plasma cells had infiltrated the peripheral zone and scattered lymphoid follicles were seen. The tumor cells had some mitoses and infiltration to the sweat glands. Immunohistochemically tumor cells were diffusely positive for CD20, CD79a and their positivity was more than three times as abundant as CD3's. There was a light chain restriction for λ-chain. The polymerase chain reaction method using DNA extracted from a paraffin section showed a rearrangement band of the IgH chain gene. After the resection the subject has never had involvement to lymph nodes or internal organs. [Skin Cancer (Japan) 2002; 17: 283-287]

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