Maternal Alcohol Administration Suppresses Expression of Nitric Oxide Synthase in the Hippocampus of Offspring Rats

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  • Jang Mi-Hyeon
    Department of Physiology, College of Medicine, Kyung Hee University
  • Lee Myoung-Hwa
    Department of Physiology, College of Medicine, Kyung Hee University
  • Kim Hong
    Department of Physiology, College of Medicine, Kyung Hee University
  • Lee Sam-Jun
    Department of Physiology, College of Medicine, Kyung Hee University
  • Sim Young-Je
    Department of Physiology, College of Medicine, Kyung Hee University
  • Kim Chang-Ju
    Department of Physiology, College of Medicine, Kyung Hee University
  • Park Se-Keun
    Department of Food & Nutrition in Oriental Medicine, Semyung University
  • Kim Jeongseon
    Department of Food & Nutrition in Oriental Medicine, Semyung University
  • Kim Ee-Hwa
    Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University

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Abstract

Maternal alcohol consumption during pregnancy can produce teratogenic effects and has a detrimental effect on the development of the fetus. In this study, the dose-dependent effect of maternal alcohol administration on the expression of nitric oxide synthase (NOS) in the hippocampus of the offspring rats was investigated. From the present result, it was shown that expression of NOS is decreased following treatment with maternal alcohol in a dose-dependent fashion. The present results suggest that suppression of NOS expression in the hippocampus of offspring rats with maternal alcohol mediates the associated developmental retardation and/or anomalies.<br>

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