Pharmacological effects of mineralocorticoid-receptor blockers
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- Nishiyama Akira
- Department of Pharmacology, Faculty of Medicine, Kagawa University, Japan
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- Hitomi Hirofumi
- Department of Pharmacology, Faculty of Medicine, Kagawa University, Japan
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- Rahman Asadur
- Department of Pharmacology, Bangladesh Agricultural University, Bangladesh
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- Kiyomoto Hideyasu
- Department of CardioRenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Japan
書誌事項
- タイトル別名
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- Drug Discovery for Overcoming Chronic Kidney Disease (CKD):Pharmacological Effects of Mineralocorticoid-Receptor Blockers
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抄録
There is increasing evidence demonstrating that the renoprotective effects of mineralocorticoid receptor (MR) blockade are independent of the effects exerted by renin-angiotensin inhibitors. MR is expressed not only in tubular cells but also in other renal cells including glomerular mesangial cells, podocytes, and renal interstitial fibroblasts. Animal experiments have shown that MR blockers prevent aldosterone-induced proteinuria, glomerular injury, and tubulointerstitial fibrosis. In vitro studies have also demonstrated that MR blockers inhibit aldosterone-induced renal cell damage. Recent clinical studies have shown that treatment with MR blockers attenuates the development of proteinuria in patients with chronic kidney disease (CKD) and hypertension, independent of changes in blood pressure. In some cases, MR blockers elicit potent renoprotective effects in conditions where aldosterone levels are not elevated. These data suggest that treatment with MR blockers may possibly present an effective therapeutic strategy for patients with CKD.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 109 (1), 1-6, 2009
公益社団法人 日本薬理学会
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詳細情報
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- CRID
- 1390282680155065088
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- NII論文ID
- 10025733131
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BD1MXhs1Ojtrs%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 9772946
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- PubMed
- 19151533
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可