"Bio-communication" Between Mother and Offspring: Lessons From Animals and New Perspectives for Brain Science

DOI Web Site 被引用文献2件 参考文献64件
  • Tozuka Yusuke
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan Japan Association for the Advancement of Medical Equipment, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Japan
  • Wada Etsuko
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Japan
  • Wada Keiji
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Japan

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Early brain development has a tremendous impact on the success of humans throughout their lives. During early development, neural circuit formation proceeds in a strictly regulated manner. In addition to genetic and epigenetic programs, recent studies using animal models have demonstrated that certain maternal bio-active agents are essential for normal neural development, with deficiencies adversely affecting offspring brain function and behavior. On the basis of these findings, we propose a new viewpoint: that maternal bio-active substances support the development of the fetal and neonatal brain, and the subsequent expression and maintenance of higher brain functions. We term these molecular-based biological conversations between mother and offspring “bio-communications”. Based on findings obtained primarily from animal models, we review the effects of maternal substances on the neural developments and functions. Clarifying the regulatory mechanisms of “bio-communications” will help improve understanding of the mechanisms of human brain functioning and neural development. In addition, these findings will be applied to elucidate the mechanisms of developmental disorders and to explore new medical therapies to treat them.<br>

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