Aspirin modulation of IgE-dependent mast cell activation: role of aspirin-induced exacerbation of immediate allergy

• Suzuki Yoshihiro

  Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, Japan

• Ra Chisei

  Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, Japan

書誌事項

タイトル別名

• Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment:Aspirin Modulation of IgE-Dependent Mast Cell Activation: Role of Aspirin-Induced Exacerbation of Immediate Allergy

抄録

Aspirin (acetylsalicylic acid) is a well-known nonsteroidal anti-inflammatory drug that can potentiate some acute allergies and causes adverse immunological reactions collectively referred to as aspirin intolerance, a disorder that induces urticaria, asthma, and anaphylaxis in response to oral administration of the drug. Aspirin also potentiates some acute allergies such as food-dependent exercise-induced anaphylaxis (FDEIA), a food allergy induced by physical exercise. The anti-inflammatory actions as well as the adverse immunological effects have been thought to be primarily due to inhibition of cyclooxygenase activity. However, a growing body of evidence suggests that mechanisms unrelated to inhibition of prostaglandin synthesis are involved. One key feature of aspirin intolerance is the overproductions of cysteinyl leukotrienes (LTs), in which mast cells have been implicated to play a role. In this review, we provide an overview of our current knowledge about the regulatory mechanisms of LTC₄ secretion in mast cells and its modulation by aspirin, with a special emphasis on the role of Ca²⁺ signals. We also introduced our recent findings that mast cells express dihydropyridine-sensitive L-type Ca²⁺ channels (LTCCs) and that Ca²⁺ channels of this kind mediate aspirin modulation of LTC₄ secretion in mast cells.<br>

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 110 (3), 237-244, 2009

  公益社団法人 日本薬理学会

キーワード

• mast cell
• aspirin
• L-type Ca²⁺ channel
• leukotriene
• allergic inflammation

詳細情報

• CRID: 1390282680155409536
• NII論文ID: 10025737336
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.08r32fm
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 10283241
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10283241
• Web Site: https://search.jamas.or.jp/link/ui/2010012263
• 本文言語コード: en
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