Low Incidence of Cardiac Events in Statin-Administered Patients in CAG Study
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- Saeki Tomoaki
- Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
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- Sakuma Nagahiko
- Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
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- Hayakawa Kiyoshi
- Department of Cardiovascular Medicine, Gamagori City Hospital, Aichi, Japan
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- Itou Kenichi
- Department of Cardiovascular Medicine, Gamagori City Hospital, Aichi, Japan
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- Wakami Kazuaki
- Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
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- Tamai Nozomu
- Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
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- Kimura Genjiro
- Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
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Aim: The effect of statins in preventing cardiac events in Japanese coronary artery disease (CAD) patients was studied in a retrospective investigation of 148 patients diagnosed with CAD by coronary angiography (CAG).<BR>Methods: Sixty-five patients received statins within 2 weeks after CAG, and 83 patients did not receive statins after CAG.<BR>Results: In the statin group, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were reduced significantly with statin administration (p<0.01). In the non-statin group, baseline levels of TC, LDL-C and high-density lipoprotein cholesterol were not changed significantly at the end of the follow-up period. As for the effect of statin in preventing cardiac events, the incidence of cardiac events was significantly lower (p<0.0003) in the statin group (n=5: 8%) than in the non-statin group (n=28: 34%). In subanalysis of 37 patients whose TC at the time of initial CAG was less than 200 mg/dL, none of the statin group (n=17) suffered a cardiac event. This was significantly lower than the incidence of cardiac events in the non-statin group (n=5: 25%; p<0.05).<BR>Conclusion: The present study demonstrated that lowering LDL-C of Japanese CAD patients by statin administration is effective to prevent cardiac events, particularly, a second percutaneous coronary intervention (PCI) for restenosis of a coronary artery following the initial PCI whether or not these patients had hypercholesterolemia.
収録刊行物
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- Journal of Atherosclerosis and Thrombosis
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Journal of Atherosclerosis and Thrombosis 16 (3), 172-178, 2009
一般社団法人 日本動脈硬化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204433487744
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- NII論文ID
- 10025765375
- 130004444272
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- NII書誌ID
- AA11018976
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- DOI
- 10.5551/jat.e565
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- COI
- 1:STN:280:DC%2BD1Mrhs1Cruw%3D%3D
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- ISSN
- 18803873
- 13403478
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- PubMed
- 19556725
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可