Association of Lipoprotein-associated Phospholipase A2 with Coronary Calcification among American and Japanese Men

DOI Web Site 2 Citations 46 References
  • El-Saed Aiman
    Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh.
  • Sekikawa Akira
    Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh. Department of Health Science, Shiga University of Medical Science.
  • Zaky Riad Wahid
    Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh.
  • Kadowaki Takashi
    Department of Health Science, Shiga University of Medical Science.
  • Takamiya Tomoko
    Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh.
  • Okamura Tomonori
    Department of Health Science, Shiga University of Medical Science.
  • Edmundowicz Daniel
    Preventive Cardiology, Cardiovascular Institute, University of Pittsburgh Medical Center Health Plan.
  • Kita Yoshikuni
    Department of Health Science, Shiga University of Medical Science.
  • Kuller Lewis H.
    Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh.
  • Ueshima Hirotsugu
    Department of Health Science, Shiga University of Medical Science.

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Abstract

BACKGROUND: We have previously reported that the prevalence of coronary artery calcification (CAC) was substantially lower among Japanese than American men despite a less favorable profile of many traditional risk factors in Japanese men. To determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are related to the difference in the prevalence of CAC between the two populations.<br>METHODS: A total of 200 men aged 40-49 years were examined: 100 residents in Allegheny County, Pennsylvania, United States, and 100 residents in Kusatsu City, Shiga, Japan. Coronary calcium score (CCS) was evaluated by electron-beam tomography, Lp-PLA2 levels, nuclear magnetic resonance (NMR) lipoprotein subclasses, and other factors were assessed in 2001-2002.<br>RESULTS: Lp-PLA2 levels were higher among American than Japanese men (Mean ± standard deviation 301.7 ± 82.6 versus 275.9 ± 104.7 ng/mL, respectively, p=0.06). Among all Japanese men and those with low density lipoprotein (LDL) cholesterol ≥130 mg/dL, there was an inverse association of the prevalence of CCS>0 with the tertile groups of Lp-PLA2 levels (p=0.08 and p=0.03, respectively). American men did not have any association between CCS>0 with the tertile groups of Lp-PLA2 (p=0.62). Although Lp-PLA2 among both populations correlated positively with LDL and total cholesterol, American and Japanese men had different correlations with NMR lipoprotein subclasses. Reported high odds ratio for CCS>0 among American compared to Japanese men was not reduced after adjusting for Lp-PLA2 levels.<br>CONCLUSION: Lp-PLA2 may have different mechanisms of action among American and Japanese men. Lp-PLA2 levels can not explain the observed CAC differences between the two populations.<br>J Epidemiol 2007; 17: 179-185.

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