Uric Acid and Left Ventricular Hypertrophy in Japanese Men

• Mitsuhashi Hirotsugu

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Department of Cardiology, Nagoya University Graduate School of Medicine

• Yatsuya Hiroshi

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine

• Matsushita Kunihiro

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Department of Cardiology, Nagoya University Graduate School of Medicine

• Zhang Huiming

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine

• Otsuka Rei

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Department of Epidemiology, National Center for Geriatrics and Gerontology, Institute for Longevity Sciences

• Muramatsu Takashi

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Department of Cardiology, Nagoya University Graduate School of Medicine

• Takefuji Seiko

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine

• Hotta Yo

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine

• Kondo Takahisa

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Murohara Toyoaki

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Toyoshima Hideaki

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Health Care Center of Anjo Kosei Hospital

• Tamakoshi Koji

  Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine Department of Nursing, Nagoya University School of Health Sciences

Abstract

Background: Experimental studies have reported that allopurinol protects hypertensive rats from left ventricular hypertrophy (LVH) with negligible effects on blood pressure (BP). Uric acid (UA) was thought to induce cardiomyocyte growth and interstitial fibrosis of the heart, partly via activation of the renin-angiotensin system. In the present study, the relationship between serum UA levels and electrocardiographically-diagnosed LVH (ECG-LVH) was examined in Japanese men not taking medication for hypertension (HTN), which could confound the association. Methods and Results: A total of 3,305 male workers aged 35-66 years (mean age ± SD, 48.0 ±7.1) were studied. LVH was defined as meeting the ECG criteria (ie, Sokolow-Lyon voltage and/or Cornell voltage QRS duration product). Subjects were divided into 3 groups by tertile of serum UA level. The highest tertile (UA range 0.39-0.65 mmol/L or 6.6-11.0 mg/dl) had a significantly increased prevalence of LVH compared with the lowest tertile independent of age, body mass index, serum creatinine level, HTN, diabetes and hyperlipidemia (odds ratio 1.58, 95% confidence interval 1.23-2.02, P<0.001). Similar results were obtained in both the normal and high BP subgroups. Conclusions: UA concentration independently and positively associated with ECG-LVH in Japanese men. (Circ J 2009; 73: 667 - 672)<br>

Journal

• Circulation Journal

  Circulation Journal 73 (4), 667-672, 2009

  The Japanese Circulation Society

Keywords

• Electrocardiography
• Epidemiology
• Left ventricular hypertrophy
• Uric acid

Details

• CRID: 1390282680081799808
• NII Article ID: 10025929244
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-08-0626
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/73/4/73_CJ-08-0626/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009192895
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed