Percutaneous Treatment With Drug-Eluting Stent vs Bypass Surgery in Patients Suffering From Chronic Stable Angina With Multivessel Disease Involving Significant Proximal Stenosis in Left Anterior Descending Artery

• Yan Qiao

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Changsheng Ma

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Shaoping Nie

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Xiaohui Liu

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Junping Kang

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Qiang Lv

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Xin Du

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Rong Hu

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Yin Zhang

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Changqi Jia

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Jiahui Wu

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Xinmin Liu

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Jianzeng Dong

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Fang Chen

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Yujie Zhou

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Shuzheng Lv

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

• Fangjiong Huang

  Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University

• Chengxiong Gu

  Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University

• Xuesi Wu

  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

Abstract

Background: The aim of the present study was to compare the effects of drug-eluting stents (DES) and coronary artery bypass grafting (CABG) in patients suffering from chronic stable angina with multivessel disease, involving significant proximal stenosis in the left anterior descending artery (LAD). Methods and Results: All consecutive patients suffering from chronic stable angina with multivessel disease involving significant proximal LAD stenosis underwent DES implantation (n=600) or CABG (n=709) at our institution. At 2 years, the unadjusted mortality was significantly lower in the DES group than in the CABG group (2.2% vs 5.2%, P=0.004), but the adjusted risk of death was similar (odds ratio (OR) 0.74, 95%CI 0.28-1.97, P=0.555). Furthermore, both the adjusted rate of nonfatal myocardial infarction and cerebrovascular events was also comparable. However, the unadjusted and adjusted risk of major adverse cardiac cerebrovascular events in the DES was significantly higher than in the CABG (13.3% vs 9.6%, OR 2.71, 95%CI 1.56-4.74, P<0.001), which is probably attributed to the higher subsequent revascularization rate after DES implantation. Conclusions: DES showed comparable long-term mortality for the treatment of multivessel disease involving significant proximal stenosis in LAD in comparison with CABG. (Circ J 2009; 73: 1848-1855)<br>

Journal

• Circulation Journal

  Circulation Journal 73 (10), 1848-1855, 2009

  The Japanese Circulation Society

Keywords

• Coronary artery bypass grafting
• Coronary artery disease
• Drug-eluting stent
• Percutaneous coronary intervention

Details

• CRID: 1390282680081595776
• NII Article ID: 10025935954
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-08-1060
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/73/10/73_CJ-08-1060/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010070609
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed