Incremental Prognostic Value of Stress/Rest Gated Perfusion SPECT in Patients With Coronary Artery Disease Subanalysis of the J-ACCESS Study

• Hashimoto Akiyoshi

  Sapporo Medical University School of Medicine

• Nakata Tomoaki

  Sapporo Medical University School of Medicine Hokkaido Prefectural Esashi Hospital

• Wakabayashi Takeru

  Sapporo Medical University School of Medicine

• Kusuoka Hideo

  Osaka National Hospital

• Nishimura Tsunehiko

  Graduate School of Medical Science, Kyoto Prefectural University of Medicine

書誌事項

タイトル別名

• Subanalysis of the J-ACCESS Study

抄録

Background: This study aimed to reveal the incremental prognostic implications of perfusion/function variables by stress/rest gated single-photon emission computed tomography (SPECT) over clinical risks in patients with known coronary artery disease (CAD). Methods and Results: Using the Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS) database, the 3-year follow-up data of 2,200 patients who had established CAD were analyzed. Major cardiac events (cardiac death, myocardial infarction, heart failure, and unstable angina) were observed in 167 (7.6%) patients. Multivariate logistic regression analysis identified peripheral artery disease, diabetes mellitus, no use of statins, typical chest pain, pharmacological stress test, heart rate at rest, left ventricular end-systolic volume index derived from gated SPECT (LVESVI), and summed difference score (SDS) as independent significant predictors of the major cardiac events, with odds ratios of 1.025 to 2.291 (P=0.0309-0.0008). Global chi-square values increased by combining the independent predictors, and the greatest values (nearly 110) were observed when LVESVI or SDS was added to the pre-scan clinical information. Conclusions: Perfusion/function measures by stress/rest gated SPECT contribute to a significant improvement in risk stratification and secondary prevention strategy in combination with pre-scan clinical risks in patients with known CAD. (Circ J 2009; 73: 2288-2293)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 73 (12), 2288-2293, 2009

  一般社団法人 日本循環器学会

キーワード

• Coronary artery disease
• Japanese
• Prognosis
• Single-photon emission computed tomography (SPECT)

詳細情報

• CRID: 1390282680079182336
• NII論文ID: 10025938421
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-09-0212
• COI: 1:STN:280:DC%2BD1MjotVaquw%3D%3D
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 19797824
• Web Site: http://www.jstage.jst.go.jp/article/circj/73/12/73_CJ-09-0212/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010113124
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可