Upregulation of Monocyte Tissue Factor Activity Is Significantly Associated With Low-Grade Chronic Inflammation and Insulin Resistance in Patients With Metabolic Syndrome

• Nakagomi Akihiro

  Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School

• Sasaki Mihoko

  Department of Pharmaceutical, Tokyo University of Pharmacy and Life Science

• Ishikawa Youhei

  Department of Pharmaceutical, Tokyo University of Pharmacy and Life Science

• Morikawa Masako

  Department of Pharmaceutical, Tokyo University of Pharmacy and Life Science

• Shibui Toshiyuki

  Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School

• Kusama Yoshiki

  Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School

• Atarashi Hirotsugu

  Department of Internal Medicine and Cardiology, Tama-Nagayama Hospital, Nippon Medical School

• Mizuno Kyoichi

  Division of Cardiology, Hepatology, Geriatrics, and Integrated Medicine, Department of Internal Medicine, Nippon Medical School

抄録

Background: The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors closely linked to inflammation and insulin resistance (IR). Tissue factor (TF) is an initiator of the extrinsic coagulation cascade and is expressed on peripheral blood monocytes and macrophages in atherosclerotic plaques. Monocytes are the principle cells capable of TF synthesis. Therefore, TF plays an important role in both thrombosis and atherosclerosis. Elevated levels of lipopolysaccharide (LPS), a strong stimulator of TF, have been observed in patients with MetS. No study has investigated the relationship between monocyte TF activity and inflammation, and IR in MetS. Methods and Results: Peripheral blood mononuclear cells (PBMCs) were collected from 40 normal subjects and 77 patients with MetS. Mononuclear cell TF procoagulant activity (MPCA) was measured with and without 100 pg/ml LPS stimulation using a 1-stage clotting assay and expressed as the mean ± SD (mU TF/10⁶ PBMCs). MPCA in MetS was significantly greater than in normal subjects (without LPS: 88.0±74.8 vs 52.6±9.8 mU TF/10⁶ PBMCs, P<0.001; with LPS: 269.6±165.6 vs 158.6±42.8 mU TF/10⁶ PBMCs, P<0.001). The LPS-stimulated log MPCA in MetS patients was significantly associated with homeostasis model assessment of IR (r=0.256, P=0.024) and log high-sensitivity C-reactive protein (r=0.332, P=0.003). Conclusions: Upregulation of monocyte TF is significantly associated with low-grade inflammation and IR in MetS. (Circ J 2010; 74: 572 - 577)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 74 (3), 572-577, 2010

  一般社団法人 日本循環器学会

キーワード

• Inflammation
• Insulin resistance
• Metabolic syndrome
• Tissue factor

詳細情報

• CRID: 1390282680081403264
• NII論文ID: 10025943852
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-09-0835
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/74/3/74_CJ-09-0835/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010209861
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可