Green Tea Catechins Improve Human Forearm Endothelial Dysfunction and Have Antiatherosclerotic Effects in Smokers

• Oyama Jun-ichi

  Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University

• Maeda Toyoki

  Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University

• Kouzuma Kazuya

  Kao Corporation

• Ochiai Ryuji

  Kao Corporation

• Tokimitsu Ichiro

  Kao Corporation

• Higuchi Yoshihiro

  Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University

• Sugano Masahiro

  Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University

• Makino Naoki

  Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University

抄録

Background: Because green tea reduces cardiovascular and cerebrovascular risk, the purpose of this study aimed to elucidate the effect of green tea catechins (GTC) on endothelial dysfunction in smokers. Methods and Results: The 30 healthy male smokers were divided into 3 groups and given green tea beverages containing 0 mg (control group), 80 mg (medium-dose group) or 580 mg (high-dose group) of GTC daily for 2 weeks. Endothelial-dependent and- independent vasodilatation was investigated by measuring the forearm blood flow (FBF) responses to acetylcholine and sodium nitroprusside using venous occlusion strain-gauge plethysmography. The FBF response to acetylcholine significantly increased at 2 h and 1 and 2 weeks after GTC intake in the high-dose group, but no increase was observed in the other groups. FBF responses to sodium nitroprusside did not alter in any group at any time point. A significant increase in plasma nitric oxide and a decrease in asymmetrical dimethylarginine, malondealdehyde and 4-hydroxynonenal, C-reactive protein, monocyte chemotactic protein-1, and soluble CD40 ligand levels were detected after chronic consumption of high-dose GTC. Conclusions: GTC have antiatherosclerotic effects on dysfunctional vessels in smokers through increasing the level of nitric oxide and reducing oxidative stress. (Circ J 2010; 74: 578 - 588)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 74 (3), 578-588, 2010

  一般社団法人 日本循環器学会

キーワード

• Atherosclerosis
• Endothelial dysfunction
• Green tea catechins
• Oxidative stress
• Smoking

詳細情報

• CRID: 1390001205104726912
• NII論文ID: 10025943880
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-09-0692
• COI: 1:CAS:528:DC%2BC3cXjvFWju7s%3D
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 20134098
• Web Site: http://www.jstage.jst.go.jp/article/circj/74/3/74_CJ-09-0692/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010209862
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可