タキソテール注射液調製時における効率化の検討

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  • Study on Improving Efficiency in Preparation of TAXOTERE Injection

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In order to improve efficiency in the preparation of TAXOTERE® injection for alcohol hypersensitive patients,we investigated its dissolution in warmed saline or 5% glucose solution.Solutions were heated to 3 different temperatures : 25°C,55 °C and 70°C.At 55°C and 70°C,for both warmed saline and 5% glucose,uniform TAXOTERE® premix solutions were obtained within 1 minute,while 10 minutes or more was required at 25°C.Further,to obtain uniform TAXOTERE® premix solutions at 55°C and 70°C only gentle mixing was necessary.There was no need for vigorous shaking.<br>We then investigated the stability of docetaxel hydrate in warmed TAXOTERE® premix solutions using HPLC.No peak for docetaxel hydrate was observed in the case of heating at 25°C for 24 hours or for heating at 55°C heating for 3 hours,for both warmed saline and 5% glucose.At 70°C,peaks assumed to be those of catabolites of docetaxel hydrate were apparent after 60 minutes.<br>In conclusion,we consider that the use of warmed saline or 5% glucose solution at 55°C in the preparation of TAXOTERE® injection for alcohol hypersensitive patients can shorten the preparation time,and greatly raise efficiency in preparation.

収録刊行物

  • 医療薬学

    医療薬学 35 (6), 431-435, 2009

    一般社団法人日本医療薬学会

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