Flow cytometric analysis of skin blister fluid induced by mosquito bites in a patient with chronic active Epstein-Barr virus infection

• Wada, Taizo

• Yokoyama, Tadafumi

• Nakagawa, Hiroyasu

• Asai, Erika

• Taga, Akiko

• Sakakibara, Yasuhisa

• Shibata, Fumie

• Tone, Yumi

• Shimizu, Masaki

• Toma, Tomoko

• Yachie, Akihiro

抄録

金沢大学医薬保健研究域医学系

In chronic active Epstein-Barr virus (EBV) infection (CAEBV), ectopic EBV infection has been described in T or natural killer (NK) cells. NK cell-type infection (NK-CAEBV) is characterized by large granular lymphocytosis, high IgE levels and unusual reactions to mosquito bites, including severe local skin reactions, fever and liver dysfunction. However, the mechanisms underlying these reactions remain undetermined. Herein, we describe a patient with NK-CAEBV whose blister fluid after mosquito bites was analyzed. The patient exhibited significant increases in the percentage of CD56+ NK cells in the fluid compared with a simple mosquito allergy, in which the majority of infiltrated cells were CD203c+ cells, indicating basophils and/or mast cells. His fluid also contained CD203c+ cells, and his circulating basophils were activated by mosquito extracts in vitro. These results suggest that CD203c+ cells as well as NK cells may play pathogenic roles in the severe skin reactions to mosquito bites in NK-CAEBV. © 2009 The Japanese Society of Hematology.

出版者に照会中.2010年12月より全文公開予定.

収録刊行物

• International Journal of Hematology

  International Journal of Hematology 90 (5), 611-615, 2009-12-01

  The Japanese Society of Hematology = 日本血液学会

キーワード

• CD203c
• Chronic active Epstein-Barr virus infection
• Mosquito bites
• NK cells
• Skin blister

詳細情報

• CRID: 1050564285907276288
• NII論文ID: 10026110032
• NII書誌ID: AA10797094
• ISSN: 09255710
• Web Site: http://hdl.handle.net/2297/20517
• Web Site: https://search.jamas.or.jp/link/ui/2010166875
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles