Impact of Changes in Waist Circumference and BMI over One-Year Period on Serum Lipid Data in Japanese Individuals

• Ishizaka Nobukazu

  Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine.

• Ishizaka Yuko

  Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital.

• Toda Ei-Ichi

  Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital.

• Koike Kazuhiko

  Department of Gastroenterology, University of Tokyo Graduate School of Medicine.

• Nagai Ryozo

  Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine.

• Yamakado Minoru

  Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital.

抄録

Aim: Loss or gain in obesity indexes, such as body mass index (BMI) and waist circumference (WC), may affect serum lipid parameters. We therefore analyzed the impact of changes in WC and BMI over a one-year period on serum levels of LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and triglycerides (TG).<BR>Methods: We analyzed the data of 3,111 individuals who were not on lipid- lowering medication and who underwent general health screening two years running.<BR>Results: The correlation between percent changes of WC (%dWC) and BMI (%dBMI) were both statistically significantly correlated with percent changes in LDL-C (%dLDL), HDL-C (%dHDL), and TG (%dTG) except that between %dWC and %dHDL in women. In multiple regression analysis, %dBMI, but not %dWC, was found to be an independent predictor of %dLDL, %dHDL, and %dTG. When %dBMI was excluded from the variables, %dWC was identified as an independent factor predicting %dLDL and %dTG; however, in individuals with %dBMI of ≥0, %dWC was not found to be a predictor of percent changes in any lipid parameters tested in this model.<BR>Conclusion: Percent changes in BMI were found to be an independent predictor of adverse changes in lipid parameters in both genders. Although percent changes in WC (%dWC) also tended to confer adverse changes in lipid parameters, this relationship did not remain statistically significant after controlling for %dBMI. It is suggested that changes in obesity parameters are an important goal to avoid adverse lipid changes, although there might be some gender differences.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 16 (6), 764-771, 2009

  一般社団法人 日本動脈硬化学会

キーワード

• Waist circumference
• Body mass index
• LDL-C
• Health screening

詳細情報

• CRID: 1390001204431792000
• NII論文ID: 130004444345
• NII論文ID: 10026144211
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.2428
• ISSN: 18803873
• ISSN: 13403478
• Web Site: https://www.jstage.jst.go.jp/article/jat/16/6/16_2428/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010152996
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可