Lower High-Density Lipoprotein Cholesterol is a Significant and Independent Risk for Coronary Artery Disease in Japanese Men

• Satoh Hiroki

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine. Department of Public Health, Hokkaido University Graduate School of Medicine.

• Tomita Kazuo

  Health Management Center, NTT East Japan Sapporo Hospital.

• Fujii Satoshi

  Department of Molecular and Cellular Pathobiology and Therapeutics, Nagoya City University Graduate School of Pharmaceutical Sciences.

• Kishi Reiko

  Department of Public Health, Hokkaido University Graduate School of Medicine.

• Tsutsui Hiroyuki

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine.

Abstract

Aim: Lower levels of high-density lipoprotein cholesterol (HDL-C) have been recognized as a risk factor for coronary artery disease (CAD), but the relationship between HDL-C values and the occurrence of CAD has not been fully established in the Japanese general population.<BR>Methods: A cohort study of 5,371 Japanese men with 12 years of follow-up was conducted to identify risk factors for the occurrence of CAD.<BR>Results: One hundred and twelve subjects had CAD (acute myocardial infarction in 67 patients and angina in 45 patients) during the follow-up period. Adjustment for variables including age, body mass index, smoking habit, alcohol intake, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, fasting plasma glucose, hypertension, diabetes mellitus and hyperlipidemia, adjusted hazard ratio (HR) of lower levels of HDL-C for the occurrence of CAD was 1.21 (95% confidence interval (CI): 1.11-1.33, p<0.001). Serum HDL-C concentration less than 51 mg/dL was a significant risk for CAD.<BR>Conclusions: Low HDL-C was identified as a significant and independent risk for CAD in Japanese men using long-term follow-up data.

Journal

• Journal of Atherosclerosis and Thrombosis

  Journal of Atherosclerosis and Thrombosis 16 (6), 792-798, 2009

  Japan Atherosclerosis Society

Keywords

• Coronary artery disease
• High-density lipoprotein cholesterol
• Primary prevention
• Japanese population

Details

• CRID: 1390282679408497920
• NII Article ID: 130004444348
• NII Article ID: 10026144298
• NII Book ID: AA11018976
• DOI: 10.5551/jat.1644
• ISSN: 18803873
• ISSN: 13403478
• Web Site: https://www.jstage.jst.go.jp/article/jat/16/6/16_1644/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010152999
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed