Effects of pregnancy and lactation on warfarin-induced changes in blood coagulation-related parameters in rats

• Ohishi Takumi

  Toxicology Department, Gotemba Laboratory, Bozo Research Center Inc.

• Kitazawa Takahiro

  Toxicology Department, Gotemba Laboratory, Bozo Research Center Inc.

• Suzuki Saori

  Toxicology Department, Gotemba Laboratory, Bozo Research Center Inc.

• Nakamura Daichi

  Toxicology Department, Gotemba Laboratory, Bozo Research Center Inc.

• Nishihara Yoshito

  Toxicology Department, Gotemba Laboratory, Bozo Research Center Inc.

• Mochizuki Masahiro

  Toxicology Department, Gotemba Laboratory, Bozo Research Center Inc.

抄録

Effects of pregnancy and lactation on warfarin-induced changes in blood coagulation-related parameters were examined in rats. Warfarin (0.5 mg/kg/day) was given orally to pregnant and non-pregnant rats for 3 days from gestation day (GD) 17 to 19 or to lactating and non-pregnant rats for 3 days from post partum day (PPD) 10 to 12. Blood samples were collected from the rats on the day following the last administration (GD 20 or PPD 13) to measure prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombotest (TBT), factor VII and X activities and anti-thrombin III concentration (ATIII). Administration of warfarin to non-pregnant rats resulted in significant prolongation of APTT and TBT and significant decreases in factor VII and X activities. On the other hand, similar but not significant changes were observed in pregnant rats and similar significant but less prominent changes were observed in lactating rats. The reduction of the anticoagulant effects of warfarin may partially be related to high plasma 17β-estradiol concentration in pregnant rats and to high plasma prolactin concentration in lactating rats, respectively.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 35 (2), 189-196, 2010

  一般社団法人　日本毒性学会

キーワード

• Warfarin
• Pregnancy
• Lactation
• Blood coagulation
• Rat

詳細情報

• CRID: 1390282679877942656
• NII論文ID: 10026193274
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.35.189
• ISSN: 18803989
• ISSN: 03881350
• NDL書誌ID: 10651922
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10651922
• Web Site: http://www.jstage.jst.go.jp/article/jts/35/2/35_2_189/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010278638
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可