NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Modulates the Effects of Coffee Consumption on the Risk of Hypertension in Middle-Aged Japanese Men

• Kokaze Akatsuki

  Department of Public Health, Showa University School of Medicine Department of Public Health, Kyorin University School of Medicine

• Ishikawa Mamoru

  Department of Public Health, Kyorin University School of Medicine Mito Red Cross Hospital

• Matsunaga Naomi

  Department of Public Health, Kyorin University School of Medicine

• Karita Kanae

  Department of Public Health, Kyorin University School of Medicine

• Yoshida Masao

  Department of Public Health, Kyorin University School of Medicine

• Ohtsu Tadahiro

  Department of Public Health, Showa University School of Medicine

• Shirasawa Takako

  Department of Public Health, Showa University School of Medicine

• Sekii Hideaki

  Department of Public Health, Showa University School of Medicine

• Ito Taku

  Department of Public Health, Showa University School of Medicine

• Kawamoto Teruyoshi

  Department of Public Health, Showa University School of Medicine

• Takashima Yutaka

  Department of Public Health, Kyorin University School of Medicine

抄録

Background: Habitual coffee consumption has been reported to lower blood pressure in the Japanese population. The NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity and modifies the effects of alcohol consumption on blood pressure in the Japanese population. The objective of this study was to determine whether this polymorphism also modifies the effects of coffee consumption on blood pressure or the risk of hypertension in middle-aged Japanese men.<BR>Methods: A total of 398 men (mean age ± standard deviation, 53.8 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. Hypertension was defined as a systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or antihypertensive drug treatment. Polymerase chain reaction-restriction fragment length polymorphism using the restriction enzyme AluI was performed to determine ND2-237 Leu/Met genotype.<BR>Results: In subjects with ND2-237Leu, coffee consumption was significantly and negatively associated with diastolic blood pressure (P = 0.007). The odds ratio (OR) for hypertension was significantly lower in subjects with ND2-237Leu who consumed 2 or 3 cups of coffee per day than in those who consumed less than 1 cup of coffee per day (OR, 0.517; 95% confidence interval [CI], 0.276 to 0.968; P = 0.039). After adjustment, the OR remained significant (OR = 0.399; 95% CI, 0.184 to 0.869; P = 0.020). Moreover, after adjustment, the OR was significantly lower in subjects with ND2-237Leu who consumed more than 4 cups of coffee per day than in those who consumed less than 1 cup of coffee per day (OR, 0.246; 95% CI, 0.062 to 0.975; P = 0.046). However, the association between ND2-237Met genotype and hypertension did not depend on coffee consumption.<BR>Conclusions: The present results suggest that the ND2-237 Leu/Met polymorphism modulates the effects of coffee consumption on hypertension risk in middle-aged Japanese men.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ 19 (5), 231-236, 2009

  日本疫学会

キーワード

• coffee consumption
• hypertension
• NADH dehydrogenase
• polymorphism
• personalized preventive medicine

詳細情報

• CRID: 1390001204475112704
• NII論文ID: 10026250668
• NII書誌ID: AA10952696
• DOI: 10.2188/jea.je20081040
• ISSN: 13499092
• ISSN: 09175040
• Web Site: https://www.jstage.jst.go.jp/article/jea/19/5/19_JE20081040/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010111856
• 本文言語コード: en
• データソース種別:
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