自然発症高血圧ラットにおける米糠発酵エキス配合飲料の血圧上昇抑制作用  [in Japanese] Antihypertensive Effect of Honey-Based Beverage Containing Fermented Rice Bran in Spontaneously Hypertensive Rats  [in Japanese]

γ-アミノ酪酸（GABA）含有米糠発酵エキスを配合した飲料の血圧上昇抑制作用を検証することを目的として，高血圧自然発症ラットを用いた実験を行った．ラットの体重1kg当たり10.1mgのGABAを含む飲料を1日1回強制経口投与し，8週間飼育した．GABAを含む飲料を摂取した群は対照飲料を摂取した群に対して3週目から低値を示した．試験7週目の血圧は，対照群の234mmHgに対して　GABA摂取群は218mmHgであり，有意な低値であった．以上の結果より，GABA含有米糠発酵エキスを配合した飲料は，血圧上昇抑制作用を示すことが明らかとなった．

The effect of oral administration of a honey-based beverage containing γ-aminobutyric acid (GABA)-fermented rice bran on blood pressure was investigated in spontaneously hypertensive rats. The control beverage or beverage containing GABA (10.1mg/kg per day) was administered to 12-week-old male rats for 8 weeks. After 3 weeks administration, blood pressure in rats administered the GABA beverage was lower than that in the control group, while it was significantly decreased on week 7 (218 vs. 234mmHg, P<0.05). In conclusion, oral chronic administration of the GABA beverage to spontaneously hypertensive rats appears to be beneficial and may improve hypertension.