マウス単為発生胚と受精胚における発生およびグルコースとメチオニンの取込みの比較
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- Hashida Naoko
- Laboratory of Animal Biotechnology, Faculty of Agriculture, Shinshu University
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- Yuzawa Kaori
- The Sawada Women's Clinic, Nagoya Reproduction Center
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- Sawada Tomio
- The Sawada Women's Clinic, Nagoya Reproduction Center
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- Tsujii Hirotada
- Laboratory of Animal Biotechnology, Faculty of Agriculture, Shinshu University
書誌事項
- タイトル別名
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- Comparison of Development and the Incorporation of Glucose and Methionine between Parthenogenic and Fertilized Mouse Embryos
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抄録
In this study, we used SrCl2 treatment to activate mouse oocytes. The objectives of this study were to compare the development of parthenogenic and fertilized mouse embryos, and the effect of insulin-like growth factor II (IGF-II) on their development to blastocysts; glucose and methionine metabolism were also examined. Compared to normal fertilized embryos, parthenogenically developed embryos exhibited delayed development, reduced total cell number, and reduced trophectoderm cell (TC) and inner cell mass (ICM) cell numbers of blastocysts. Supplementation of IGF-II to the culture medium enhanced parthenogenic embryo development, cell number, and TC and ICM cell numbers but not to the same level as that of normal fertilized embryos (P < 0.05). Incorporation and oxidation of glucose and protein synthesis from methionine were lower in parthenogenic blastocysts than in fertilized blastocysts (P < 0.05).<br>
収録刊行物
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- 日本哺乳動物卵子学会誌
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日本哺乳動物卵子学会誌 26 (3), 145-152, 2009
日本卵子学会
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詳細情報 詳細情報について
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- CRID
- 1390282679316034944
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- NII論文ID
- 130004436756
- 10026349849
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- NII書誌ID
- AN10548943
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- ISSN
- 13475878
- 13417738
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- NDL書誌ID
- 10510029
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可