卵成熟過程において成熟／M期促進因子活性を制御する上流因子

DOI 日本農学文献記事索引 Web Site 被引用文献1件 参考文献87件
  • Naito Kunihiko
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo
  • Nishimura Yukio
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo
  • Yamamuro Tadashi
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo
  • Shimaoka Takuma
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo
  • Fujii Wataru
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo
  • Suzuki Mari
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo
  • Nishimura Takanori
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo
  • Kano Kiyoshi
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo

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  • Upstream Factors Regulating Maturation/M-phase Promoting Factor Activity during Oocyte Maturation

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Maturation/M-phase promoting factor (MPF) activity is regulated by the Cyclin B concentration and phosphorylation states of Cdc2 kinase. In the present review, we summarize the factors regulating the synthesis and degradation of Cyclin B and the phosphorylation and dephosphorylation of Cdc2. We focuse on Aurora A and cytoplasmic polyadenylation element binding protein (CPEB), which are involved in cytoplasmic polyadenylation, for Cyclin B synthesis; on anaphase-promoting complex (APC) activating factors, FZR1 and CDC20, for Cyclin B degradation; on Cdk7 and Wee1B for Cdc2 phosphorylation, and on Cdc25 for Cdc2 dephosphorylation. We describe our recent results concerning these factors in porcine oocytes, and discusse overall regulation of MPF activity during porcine oocyte maturation.<br>

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