Effects of Gadolinium-ethoxybenzyl-diethylenetriamine Pentaacetic Acid on T2-weighted MRCP

• NAKAMURA Yuko

  Department of Radiology, Kure City Medical Association Hospital

• OHMOTO Toshifumi

  Department of Radiology, Kure City Medical Association Hospital

• SAITO Tomoko

  Department of Radiology, Kure City Medical Association Hospital

• KAJIMA Toshio

  Kajima Clinic

• NISHIMARU Eiji

  Department of Radiology, Hiroshima University Hospital

• ITO Katsuhide

  Department of Radiology, JA Onomichi General Hospital

抄録

Purpose: Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is a recently developed liver-specific contrast agent for magnetic resonance (MR) imaging that is excreted equally via the kidneys and the biliary system. To our knowledge, its effects on T₂-weighted MR cholangiopancreatography (MRCP) images have not been explored. Acquisition of the hepatobiliary phase is recommended 20 min after administration of Gd-EOB-DTPA. Examination time cannot be extended if the contrast does not take effect on T₂-weighted MRCP within 20 min after administration.<br> We attempted to assess the change in signal of T₂-weighted MRCP by excretion of Gd-EOB-DTPA.<br> Methods: Between March and July 2008, 40 patients (15 women, 25 men; mean age 70.8 years) were examined with abdominal MR imaging. T₂-weighted MRCP was performed before and 10 and 20 min after administration of Gd-EOB-DTPA. We analyzed signal intensity of the bile duct, gallbladder, cystic duct, and pancreatic duct on MRCP for changes in intensity.<br> Results: T₂-weighted MRCP 20 min after contrast administration showed loss of signal of the bile duct (intrahepatic bile duct in all cases, upper extrahepatic duct in 36 [90%], middle extrahepatic duct in 33 [85%], and lower extrahepatic duct in 26 [67%]), the gallbladder in 23 cases (72%), and the cystic duct in 25 (64%). This signal change increased with time. We observed no change in signal of the pancreatic duct.<br> Conclusion: T₂-weighted MRCP sequences should not be obtained after administration of Gd-EOB-DTPA because this contrast agent decreases signal intensity of the biliary structure on these images.<br>

収録刊行物

• Magnetic Resonance in Medical Sciences

  Magnetic Resonance in Medical Sciences 8 (4), 143-148, 2009

  日本磁気共鳴医学会

キーワード

• bile duct
• biliary excretion
• Gd-EOB-DTPA
• T₂-weighted MRCP

詳細情報

• CRID: 1390001205196707072
• NII論文ID: 10026406628
• NII書誌ID: AA11648770
• DOI: 10.2463/mrms.8.143
• ISSN: 18802206
• ISSN: 13473182
• Web Site: https://www.jstage.jst.go.jp/article/mrms/8/4/8_4_143/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010138816
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可