A 28-day oral toxicity study of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, in F344 rats
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- Hagiwara Akihiro
- DIMS Institute of Medical Science, Inc.
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- Imai Norio
- DIMS Institute of Medical Science, Inc.
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- Sano Masashi
- DIMS Institute of Medical Science, Inc.
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- Kawabe Mayumi
- DIMS Institute of Medical Science, Inc.
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- Tamano Seiko
- DIMS Institute of Medical Science, Inc.
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- Kitamura Satoshi
- San-Ei Gen F.F.I., Inc.
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- Omoto Toshio
- San-Ei Gen F.F.I., Inc.
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- Asai Iwao
- San-Ei Gen F.F.I., Inc.
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- Yasuhara Kazuo
- San-Ei Gen F.F.I., Inc.
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- Hayashi Shim-mo
- San-Ei Gen F.F.I., Inc.
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This study was designed to evaluate any adverse effect of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, when administered to both sexes of F344 rats at dietary levels of 0, 1.25, 2.5, and 5.0% for 28 days. The treatment had no adverse effects on clinical signs, mortality, body weights and food and water consumption, or on urinalysis, ophthalmology, hematology, blood biochemistry, and histopathology findings. At necropsy, slight increased absolute and relative cecum weights, evident in females ingesting 2.5% and 5.0% dietary levels, were considered to be a physiological adaptation to the poorly absorbed fermentation-derived cellulose. The non-observed-adverse-effect level (NOAEL) from the present study was concluded to be 5.0% in the diet (5,331 mg/kg body weights/day for males, and 5,230 mg/kg body weights/day for females).
収録刊行物
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- Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｔｏｘｉｃｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅｓ
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Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｔｏｘｉｃｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅｓ 35 (3), 317-325, 2010
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282679879754880
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- NII論文ID
- 10026469602
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- NII書誌ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 10731692
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
