Waon Therapy for Cardiovascular Disease: - Innovative Therapy for the 21st Century -

• Miyata Masaaki

  Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University

• Tei Chuwa

  Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University

書誌事項

タイトル別名

• – Innovative Therapy for the 21^st Century –

抄録

Waon therapy is a form of thermal treatment in a dry sauna maintained at a temperature of 60°C, which differs from the traditional sauna. Waon therapy reportedly improves the hemodynamics, cardiac function, ventricular arrhythmias, vascular endothelial function, neurohormonal factors, sympathetic nervous system function, and symptoms in patients with chronic heart failure (CHF). It has also been demonstrated that the molecular mechanism by which Waon therapy improves vascular flow and endothelial function involves increased expression of endothelial nitric oxide synthase (eNOS). Furthermore, in a mouse model of hindlimb ischemia, repeated Waon therapy increased eNOS protein expression, blood flow, and capillary density. Moreover, Waon therapy did not increase blood flow and capillary density in eNOS-deficient mice, indicating that eNOS is a critical regulator of the angiogenesis induced by this therapy. Moreover, repeated Waon therapy is effective for patients with severe peripheral arterial disease (PAD), as evidenced by substantial decrease in pain scores, increases in both ankle-brachial pressure index and blood flow assessed by laser Doppler perfusion imaging, and by formation of new collateral vessels on angiography. In addition, ischemic ulcers heal or improve markedly. In conclusion, Waon therapy is an innovative and highly promising strategy for treating CHF and PAD. (Circ J 2010; 74: 617-621)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 74 (4), 617-621, 2010

  一般社団法人 日本循環器学会

キーワード

• Chronic heart failure
• Nitric oxide
• Peripheral arterial disease
• Waon therapy

詳細情報

• CRID: 1390282680078527104
• NII論文ID: 10026471979
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-09-0939
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/74/4/74_CJ-09-0939/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010239981
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可