Standard-Dose Statin Therapy Provides Incremental Clinical Benefits in Normocholesterolemic Diabetic Patients
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- Kojima Sunao
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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- Sakamoto Tomohiro
- Divison of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center
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- Ogawa Hisao
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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- Kitagawa Akira
- Department of Clinical Trial Management, Graduate School, International University of Health and Welfare
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- Matsui Kunihiko
- Clinical Education Center, Kumamoto University Hospital
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- Shimomura Hideki
- Division of Cardiology, Fukuoka Tokushukai Hospital
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- Kimura Kazuo
- Division of Cardiology, Yokohama City University Medical Center
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- Ogata Yasuhiro
- Division of Cardiology, Japan Red Cross Kumamoto Hospital
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- Sakaino Naritsugu
- Division of Cardiology, Amakusa Medical Center
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Background: Randomized trials have established statins as an agent for prevention of coronary heart disease (CHD). The purpose of this study was to assess the hypothesis that standard-dose statin therapy has a beneficial effect in normocholesterolemic diabetic patients with CHD. Methods and Results: A prospective, randomized, open, blinded-endpoint trial was conducted from 2002 to 2004 at 55 hospitals in Japan to evaluate the effect of statins on subsequent cardiovascular events. A total number of 1,016 CHD patients (301 patients with type 2 diabetes mellitus [DM] and 715 non-DM patients) with serum total cholesterol levels of 180-240 mg/dl were randomly divided into non-statin and statin treatments. Clinical parameters were comparable between DM and non-DM groups. Serum low-density lipoprotein (LDL)-cholesterol levels were equally decreased after statin treatment in the 2 groups. Statin treatment improved prognosis in both the DM and non-DM groups; however, the number needed to treat (NNT) and relative risk reduction (RRR) were remarkable especially in the DM group (NNT=8, RRR=67%) compared with the non-DM group (NNT=30, RRR=24%). Conclusions: Standard-dose statin therapy provides incremental clinical benefits in DM patients with normal cholesterol levels compared with non-DM patients. The data suggest that DM patients may enjoy the pleiotropic effects of statins, independent of the LDL-cholesterol lowering effects of these agents. (Circ J 2010; 74: 779-785)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 74 (4), 779-785, 2010
一般社団法人 日本循環器学会
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詳細情報
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- CRID
- 1390001205101895552
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- NII論文ID
- 10026472717
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 使用不可